Glucosaminylglycan biosynthesis: what we can learn from the X-ray crystal structures of glycosyltransferases GlcAT1 and EXTL2.

@article{Negishi2003GlucosaminylglycanBW,
  title={Glucosaminylglycan biosynthesis: what we can learn from the X-ray crystal structures of glycosyltransferases GlcAT1 and EXTL2.},
  author={Masahiko Negishi and Jian Dong and Thomas A. Darden and Lee G. Pedersen and Lars C Pedersen},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={303 2},
  pages={393-8}
}
The X-ray crystal structures of two glycosyltransferases (GTs)--beta 1,3-glucuronyltransferase 1 (GlcAT1) and alpha 1,4-N-acetylhexosaminyltransferase (EXTL2)--have now been determined in the presence of both donor and acceptor substrates. These enzymes are involved in glucosaminylglycan (GAG) synthesis where they catalyze inverting and retaining transfer reactions, respectively. As members of a large family of enzymes that transfer sugar groups from donor nucleotide-sugars to acceptor… CONTINUE READING

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