Glucosamine therapy for treating osteoarthritis.

  title={Glucosamine therapy for treating osteoarthritis.},
  author={Tanveer Towheed and Lara J Maxwell and Tassos P Anastassiades and Beverley J. Shea and J Houpt and Vivian A Robinson and Marc C. Hochberg and George A Wells},
  journal={The Cochrane database of systematic reviews},
BACKGROUND Osteoarthritis (OA) is the most common form of arthritis, and it is often associated with significant disability and an impaired quality of life. OBJECTIVES To review all randomized controlled trials (RCTs) evaluating the effectiveness and toxicity of glucosamine in OA. SEARCH STRATEGY We searched MEDLINE, PREMEDLINE, EMBASE, AMED, ACP Journal Club, DARE, CDSR, and the CCTR. We also wrote letters to content experts, and hand searched reference lists of identified RCTs and… 

Glucosamine Long-Term Treatment and the Progression of Knee Osteoarthritis: Systematic Review of Randomized Controlled Trials

The available evidence suggests that glucosamine sulfate may be effective and safe in delaying the progression and improving the symptoms of knee OA.

Chondroitin for osteoarthritis.

The benefit and harm of oral chondroitin for treating osteoarthritis compared with placebo or a comparator oral medication including, but not limited to, nonsteroidal anti-inflammatory drugs (NSAIDs), analgesics, opioids, and glucosamine or other "herbal" medications are evaluated.

The use of glucosamine for chronic low back pain: a systematic review of randomised control trials

There was low quality but generally no evidence of an effect from glucosamine on function, with no change in the Roland-Morris Disability Questionnaire score in all studies.

Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network meta-analysis

The network meta-analysis suggests that diacerein and glucosamine are equally efficacious for symptom relief in knee OA, but that the former has more side effects.

Acetaminophen for osteoarthritis.

The evidence to date suggests that NSAIDs are superior to acetaminophen for improving knee and hip pain in people with OA but have not been shown to be superior in improving function.

Nutraceutical supplements in management of pain and disability in osteoarthritis: a systematic review and meta-analysis of randomized clinical trials

It is suggested that nutraceutical supplementation of patients with knee/hip OA may lead to an improvement in pain intensity and physical function.

Effects of glucosamine in patients with osteoarthritis of the knee: a systematic review and meta-analysis

The JKOM meta-analysis indicated that glucosamine is superior to a placebo in alleviating knee OA symptoms, and it was concluded thatglucosamine has the potential to alleviate knee Oa pain.

Effects of glucosamine supplements on painful temporomandibular joint osteoarthritis: A systematic review

In two studies, GS were equally effective regarding pain reduction and mouth opening improvement compared to ibuprofen taken two or three times a day over 12 weeks; however, one study did not find significant differences in follow-up evaluations concerning these clinical variables in both glucosamine and placebo groups administered over six weeks.

Efficacy of Chondroitin Sulfate in Patients with Knee Osteoarthritis: A Comprehensive Meta-Analysis Exploring Inconsistencies in Randomized, Placebo-Controlled Trials

This new meta-analysis suggests that CS provides a moderate benefit for pain and has a large effect on function in knee OA, however with large inconsistency.



Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis.

Evaluation of benefit of glucosamine and chondroitin preparations for OA symptoms using meta-analysis combined with systematic quality assessment of clinical trials of these preparations in knee and/or hip OA suggests some degree of efficacy appears probable for these preparations.

A systematic review of randomized controlled trials of pharmacological therapy in osteoarthritis of the hip.

NSAID trials in patients with OA of the hip appear to be weakened by a lack of standardization of case definition of OA, and also by the lack ofStandardization of outcome assessments.

Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis.

This study demonstrates the structural efficacy of glucosamine and indistinguishable symptomatic efficacies for both compounds in knee osteoarthritis and further studies are needed to investigate the relationship among time, dose, patient baseline characteristics, and structural efficacy for an accurate, disease-modifying characterization of these 2 compounds.

Glucosamine Sulfate for Osteoarthritis

There is evidence that glucosamine sulfate may provide pain relief, reduce tenderness, and improve mobility in patients with OA.

A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee.

As a symptom modifier in OA patients with a wide range of pain severities, glucosamine sulphate was no more effective than placebo.

Published meta-analyses of pharmacological therapies for osteoarthritis.

  • T. Towheed
  • Medicine
    Osteoarthritis and cartilage
  • 2002
The objectives of this commentary are twofold: (1) to identify which pharmacological agents used in the management of osteoarthritis (OA) have published evidence in the form of systematic reviews

Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study.

Long-term treatment with glucosamine sulfate retarded the progression of knee osteoarthritis, possibly determining disease modification.