Glucosamine therapy for treating osteoarthritis.

@article{Towheed2005GlucosamineTF,
  title={Glucosamine therapy for treating osteoarthritis.},
  author={Tanveer Towheed and Lara J Maxwell and Tassos P Anastassiades and Beverley J. Shea and J Houpt and Vivian A Robinson and Marc C. Hochberg and George A Wells},
  journal={The Cochrane database of systematic reviews},
  year={2005},
  volume={2},
  pages={
          CD002946
        }
}
BACKGROUND Osteoarthritis (OA) is the most common form of arthritis, and it is often associated with significant disability and an impaired quality of life. OBJECTIVES To review all randomized controlled trials (RCTs) evaluating the effectiveness and toxicity of glucosamine in OA. SEARCH STRATEGY We searched MEDLINE, PREMEDLINE, EMBASE, AMED, ACP Journal Club, DARE, CDSR, and the CCTR. We also wrote letters to content experts, and hand searched reference lists of identified RCTs and… 

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TLDR
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TLDR
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TLDR
The network meta-analysis suggests that diacerein and glucosamine are equally efficacious for symptom relief in knee OA, but that the former has more side effects.

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TLDR
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TLDR
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TLDR
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TLDR
In two studies, GS were equally effective regarding pain reduction and mouth opening improvement compared to ibuprofen taken two or three times a day over 12 weeks; however, one study did not find significant differences in follow-up evaluations concerning these clinical variables in both glucosamine and placebo groups administered over six weeks.

Efficacy of Chondroitin Sulfate in Patients with Knee Osteoarthritis: A Comprehensive Meta-Analysis Exploring Inconsistencies in Randomized, Placebo-Controlled Trials

TLDR
This new meta-analysis suggests that CS provides a moderate benefit for pain and has a large effect on function in knee OA, however with large inconsistency.
...

References

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Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis.

TLDR
Evaluation of benefit of glucosamine and chondroitin preparations for OA symptoms using meta-analysis combined with systematic quality assessment of clinical trials of these preparations in knee and/or hip OA suggests some degree of efficacy appears probable for these preparations.

A systematic review of randomized controlled trials of pharmacological therapy in osteoarthritis of the hip.

TLDR
NSAID trials in patients with OA of the hip appear to be weakened by a lack of standardization of case definition of OA, and also by the lack ofStandardization of outcome assessments.

Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis.

TLDR
This study demonstrates the structural efficacy of glucosamine and indistinguishable symptomatic efficacies for both compounds in knee osteoarthritis and further studies are needed to investigate the relationship among time, dose, patient baseline characteristics, and structural efficacy for an accurate, disease-modifying characterization of these 2 compounds.

Glucosamine Sulfate for Osteoarthritis

TLDR
There is evidence that glucosamine sulfate may provide pain relief, reduce tenderness, and improve mobility in patients with OA.

A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee.

TLDR
As a symptom modifier in OA patients with a wide range of pain severities, glucosamine sulphate was no more effective than placebo.

Published meta-analyses of pharmacological therapies for osteoarthritis.

  • T. Towheed
  • Medicine
    Osteoarthritis and cartilage
  • 2002
The objectives of this commentary are twofold: (1) to identify which pharmacological agents used in the management of osteoarthritis (OA) have published evidence in the form of systematic reviews

Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study.

TLDR
Long-term treatment with glucosamine sulfate retarded the progression of knee osteoarthritis, possibly determining disease modification.
...