Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study.
@article{Pavelka2002GlucosamineSU, title={Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study.}, author={Karel Pavelka and Jindři{\vs}ka Gatterov{\'a} and Marta Olej{\'a}rov{\'a} and Stanislav Mach{\'a}{\vc}ek and Giampaolo Giacovelli and Lucio Claudio Rovati}, journal={Archives of internal medicine}, year={2002}, volume={162 18}, pages={ 2113-23 } }
BACKGROUND
Conventional symptomatic treatments for osteoarthritis do not favorably affect disease progression. The aim of this randomized, placebo-controlled trial was to determine whether long-term (3-year) treatment with glucosamine sulfate can modify the progression of joint structure and symptom changes in knee osteoarthritis, as previously suggested.
METHODS
Two hundred two patients with knee osteoarthritis (using American College of Rheumatology criteria) were randomized to receive oral…
Figures and Tables from this paper
696 Citations
Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator.
- MedicineArthritis and rheumatism
- 2007
The findings of this study indicate that glucosamine sulfate at the oral once-daily dosage of 1,500 mg is more effective than placebo in treating knee OA symptoms.
Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies
- MedicineMenopause
- 2004
It is demonstrated for the first time that a pharmacological intervention for OA has a disease-modifying effect in this particular population, the most frequently affected by knee OA.
The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial.
- MedicineArthritis and rheumatism
- 2008
At 2 years, no treatment achieved a predefined threshold of clinically important difference in JSW loss as compared with placebo, however, knees with K/L grade 2 radiographic OA appeared to have the greatest potential for modification by these treatments.
The Effect of Glucosamine and / or Chondroitin Sulfate on the Progression of Knee Osteoarthritis : A GAIT Report
- Medicine
- 2011
At two years, no treatment achieved a predefined clinically important difference in JSW loss compared to placebo, however, patients with K&L Grade 2 osteoarthritis appear to have the greatest potential for modification by these treatments.
Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT
- MedicineAnnals of the rheumatic diseases
- 2010
Over 2 years, no treatment achieved a clinically important difference in WOMAC pain or function as compared with placebo, however, glucosamine and celecoxib showed beneficial but not significant trends.
Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trial.
- MedicineArthritis and rheumatism
- 2009
The long-term combined structure- modifying and symptom-modifying effects of CS suggest that it could be a disease-modification agent in patients with knee OA.
The efficacy and tolerability of glucosamine sulfate in the treatment of knee osteoarthritis: A randomized, double-blind, placebo-controlled trial.
- MedicineCurrent therapeutic research, clinical and experimental
- 2009
Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens
- MedicineAnnals of the rheumatic diseases
- 2015
Allocation to the glucosamine–chondroitin combination resulted in a statistically significant reduction in JSN at 2 years, and none of the treatment allocation groups demonstrated significant symptomatic benefit above placebo.
Efficacy of Chondroitin Sulfate for Painful Knee Osteoarthritis: A One-Year, Randomized, Double-Blind, Multicenter Clinical Study in Japan.
- MedicineBiological & pharmaceutical bulletin
- 2018
It is concluded that chondroitin sulfate is useful for pain control in knee osteoarthritis because it improved pain faster after 6 and 9 months' therapy and had good tolerability.
Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo.
- MedicineOsteoarthritis and cartilage
- 2004
References
SHOWING 1-10 OF 60 REFERENCES
Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial
- MedicineThe Lancet
- 2001
A 5-year randomized controlled, double-blind study of glycosaminoglycan polysulphuric acid complex (Rumalon) as a structure modifying therapy in osteoarthritis of the hip and knee.
- MedicineOsteoarthritis and cartilage
- 2000
It was not able to demonstrate a structure modifying effect of GP-C in OA of the hip or knee, and Radiographic progression of OA in both knee and hip OA was lower than expected in both study groups.
Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.
- MedicineOsteoarthritis and cartilage
- 1994
Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis.
- MedicineJAMA
- 2000
Evaluation of benefit of glucosamine and chondroitin preparations for OA symptoms using meta-analysis combined with systematic quality assessment of clinical trials of these preparations in knee and/or hip OA suggests some degree of efficacy appears probable for these preparations.
EFFECT OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON THE COURSE OF OSTEOARTHRITIS
- MedicineThe Lancet
- 1989
Plain radiography as an outcome measure in clinical trials involving patients with knee osteoarthritis.
- Medicine, BiologyRheumatic diseases clinics of North America
- 1999
The Bristol 'OA500' study: progression of osteoarthritis (OA) over 3 years and the relationship between clinical and radiographic changes at the knee joint.
- MedicineOsteoarthritis and cartilage
- 1997
Radiologic progression of hip and knee osteoarthritis.
- MedicineOsteoarthritis and cartilage
- 1999
This review summarizes the results obtained and the key points to consider when using plain X-rays, and Suggestions are made regarding the presentation of results and the data analysis of studies in OA using radiographic outcome assessment.
Guidelines for testing slow acting drugs in osteoarthritis.
- MedicineThe Journal of rheumatology. Supplement
- 1994
The course of the articular cartilage lesion is the primary outcome measure to be assessed in putative chondroprotective agent trials, and serial radiographic studies suggest that the annual rate of joint space narrowing in patients with hip or knee OA is about 0.25 mm.