Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study.

@article{Pavelka2002GlucosamineSU,
  title={Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study.},
  author={Karel Pavelka and Jindři{\vs}ka Gatterov{\'a} and Marta Olej{\'a}rov{\'a} and Stanislav Mach{\'a}{\vc}ek and Giampaolo Giacovelli and Lucio Claudio Rovati},
  journal={Archives of internal medicine},
  year={2002},
  volume={162 18},
  pages={
          2113-23
        }
}
BACKGROUND Conventional symptomatic treatments for osteoarthritis do not favorably affect disease progression. The aim of this randomized, placebo-controlled trial was to determine whether long-term (3-year) treatment with glucosamine sulfate can modify the progression of joint structure and symptom changes in knee osteoarthritis, as previously suggested. METHODS Two hundred two patients with knee osteoarthritis (using American College of Rheumatology criteria) were randomized to receive oral… 

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References

SHOWING 1-10 OF 60 REFERENCES
A 5-year randomized controlled, double-blind study of glycosaminoglycan polysulphuric acid complex (Rumalon) as a structure modifying therapy in osteoarthritis of the hip and knee.
TLDR
It was not able to demonstrate a structure modifying effect of GP-C in OA of the hip or knee, and Radiographic progression of OA in both knee and hip OA was lower than expected in both study groups.
Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.
Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis.
TLDR
Evaluation of benefit of glucosamine and chondroitin preparations for OA symptoms using meta-analysis combined with systematic quality assessment of clinical trials of these preparations in knee and/or hip OA suggests some degree of efficacy appears probable for these preparations.
Radiologic progression of hip and knee osteoarthritis.
TLDR
This review summarizes the results obtained and the key points to consider when using plain X-rays, and Suggestions are made regarding the presentation of results and the data analysis of studies in OA using radiographic outcome assessment.
Guidelines for testing slow acting drugs in osteoarthritis.
TLDR
The course of the articular cartilage lesion is the primary outcome measure to be assessed in putative chondroprotective agent trials, and serial radiographic studies suggest that the annual rate of joint space narrowing in patients with hip or knee OA is about 0.25 mm.
...
...