Glucosamine sulfate modulates dysregulated activities of human osteoarthritic chondrocytes in vitro.

@article{Piperno2000GlucosamineSM,
  title={Glucosamine sulfate modulates dysregulated activities of human osteoarthritic chondrocytes in vitro.},
  author={Muriel Piperno and Pascal Reboul and M-P Hellio Le Graverand and M J Peschard and Marliese Annefeld and Marie-Odile Richard and Eric P. Vignon},
  journal={Osteoarthritis and cartilage},
  year={2000},
  volume={8 3},
  pages={207-12}
}
OBJECTIVE The efficacy of glucosamine sulfate (GS) in the symptomatic treatment of patients with osteoarthritis (OA) is suggested to be mediated by still unknown effects on the altered OA cartilage. DESIGN Using human OA chondrocytes in culture, the effects of GS on protein synthesis, caseinase, collagenase, phospholipase A2 (PLA2) and protein kinase C (PKC) activities as well as production of nitric oxide and cyclic AMP were studied in both cells and culture medium. RESULTS GS… CONTINUE READING