Glucosamine reverses drug resistance in MRP2 overexpressing ovarian cancer cells.

  title={Glucosamine reverses drug resistance in MRP2 overexpressing ovarian cancer cells.},
  author={Fatemeh Valinezhad Sani and Abbas Ali Palizban and Fatemeh Mosaffa and Khadijeh Jamialahmadi},
  journal={European journal of pharmacology},
Glucosamine (GlcN), a natural amino sugar in human body, was reported to exhibit anticancer activity against some tumors. In the present study, we evaluated the cytotoxicity and multi-drug resistance (MDR) reversal activity of GlcN on resistant MRP2-overexpressing ovarian cancer A2780RCIS cells. The cytotoxicity and MDR reversal activity of GlcN on cancer cells were measured by MTT assay. The effects of GlcN on MRP1 and MRP2 mRNA expression and function were evaluated by qRT-PCR and flow… Expand
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