Glucosamine reverses drug resistance in MRP2 overexpressing ovarian cancer cells.

@article{ValinezhadSani2019GlucosamineRD,
  title={Glucosamine reverses drug resistance in MRP2 overexpressing ovarian cancer cells.},
  author={Fatemeh Valinezhad Sani and Abbas Ali Palizban and Fatemeh Mosaffa and Khadijeh Jamialahmadi},
  journal={European journal of pharmacology},
  year={2019},
  pages={
          172883
        }
}
Glucosamine (GlcN), a natural amino sugar in human body, was reported to exhibit anticancer activity against some tumors. In the present study, we evaluated the cytotoxicity and multi-drug resistance (MDR) reversal activity of GlcN on resistant MRP2-overexpressing ovarian cancer A2780RCIS cells. The cytotoxicity and MDR reversal activity of GlcN on cancer cells were measured by MTT assay. The effects of GlcN on MRP1 and MRP2 mRNA expression and function were evaluated by qRT-PCR and flow… Expand
Glucosamine attenuates drug resistance in Mitoxantrone-resistance breast cancer cells.
TLDR
It is proposed that glucosamine as a natural sugar could down regulate the BCRP expression and increased MX cytotoxicity in breast cancer cells. Expand
Label-Free Quantitative Proteomics Analysis of the Sorafenib Resistance in HepG2 Cells
Drug resistance of sorafenib seriously affects the treatment effect of late-stage hepatocellular carcinoma (HCC) patients. However, the precise mechanism of resistance to sorafenib remains unclear.Expand
Role of multidrug resistance-associated proteins in cancer therapeutics: past, present, and future perspectives
TLDR
The models used to analyze MRP transporters are outlined and a future impact that may set up a base or pave the way for many researchers to investigate the cancer MRP further is proposed. Expand
The Role of Exosomal microRNA in Cancer Drug Resistance
  • Qiao-ru Guo, Hui Wang, +7 authors Jian-ye Zhang
  • Biology, Medicine
  • Frontiers in Oncology
  • 2020
TLDR
How exosomal miRNAs regulate the drug resistance is discussed, which is one of the critical factors affecting therapeutic effect in the course of cancer treatment. Expand
Chemotherapy Resistance in Epithelial Ovarian Cancer: Mechanisms and Emerging Treatments.
TLDR
This review will present the exceptional biochemical environment implicated in OC and highlights mechanisms of chemoresistance, and innovative molecules and new therapeutic opportunities are presented, along with currently available therapies and ongoing clinical trials. Expand

References

SHOWING 1-10 OF 34 REFERENCES
Glucosamine suppresses proliferation of human prostate carcinoma DU145 cells through inhibition of STAT3 signaling
TLDR
Glucosamine is identified as a suppressor of STAT3 signaling and suggests that anticancer activity of glucosamine may be attributed to the suppression ofSTAT3 activity, which is constitutively activated in many cancer cells including DU145 cells. Expand
The novel IGF-IR/Akt–dependent anticancer activities of glucosamine
TLDR
In vivo xenograft model results suggest that targeting the IGF-1R/Akt pathway with glucosamine may be an effective therapeutic strategy for treating some type of cancer. Expand
Reversal of drug resistance in breast cancer cells by transglutaminase 2 inhibition and nuclear factor-kappaB inactivation.
TLDR
Examining several different breast cancer cell lines found that doxorubicin-resistant cells had a higher level of TGase 2 compared with dox orubicIn-sensitive cells independent of the EGFR expression level, and increased expression of TG enzyme 2 and subsequent activation of NF-kappaB may contribute to drug resistance in breast cancer cells independently of EGF signaling. Expand
Transcription factors that mediate epithelial–mesenchymal transition lead to multidrug resistance by upregulating ABC transporters
TLDR
Treatment with chemotherapeutic drugs increases the expression of several ATP binding cassette transporters associated with MDR, as well as epithelial–mesenchymal transition (EMT) markers, selectively in invasive breast cancer cells, but not in immortalized or non-invasive cells. Expand
Loss of E-cadherin in multidrug resistant breast cancer cell line MCF-7/Adr: possible implication in the enhanced invasive ability.
TLDR
The drug-resistant MCF-7/Adr cells were found to be more invasive/metastatic than their parental control, possibly related to the loss of E-cadherin expression. Expand
Glucosamine is an effective chemo-sensitizer via transglutaminase 2 inhibition.
TLDR
Glucosamine, as a TGase 2 inhibitor, might be an attractive novel target for treatment of malignant cancers because it promotes cell death in drug-resistant cancer cells through NF-kappaB inactivation. Expand
Multidrug resistance-associated protein 2 determines the efficacy of cisplatin in patients with hepatocellular carcinoma.
TLDR
In conclusion, overexpression of MRP2 correlates with a lower percentage of tumor necrosis in patients treated with cisplatin-based neoadjuvant chemotherapy for HCC, whereas either tumor size or dose of cisPlatin does not. Expand
Protective effects of glucosamine and its acetylated derivative on serum/glucose deprivation-induced PC12 cells death: Role of reactive oxygen species
TLDR
Results indicated that GlcN and GlcNAc had a cytoprotective property against SGD-induced cell death via anti-apoptosis and antioxidant activities, suggesting that these aminosugers have the potential to be used as novel therapeutic agents for neurodegenerative disorders. Expand
ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal
  • C. Choi
  • Medicine
  • Cancer Cell International
  • 2004
TLDR
In this review, the physiological functions and structures of ABC transporters, and the development of chemosensitizers are described focusing on well-known proteins including P-glycoprotein, multidrug resistance associated protein, and breast cancer resistance protein. Expand
Molecular mechanisms of anticancer effects of Glucosamine.
TLDR
This comprehensive review summarizes anti-cancer molecular mechanisms of glucosamine in details. Expand
...
1
2
3
4
...