Glucosamine-paracetamol spray-dried solid dispersions with maximized intrinsic dissolution rate, bioavailability and decreased levels of in vivo toxic metabolites

  title={Glucosamine-paracetamol spray-dried solid dispersions with maximized intrinsic dissolution rate, bioavailability and decreased levels of in vivo toxic metabolites},
  author={Ahmed Mahmoud Abdelhaleem Ali and Ahmed A Khames and Majed M. Alrobaian and Mohammad Hamaidi and Mohammed A. S. Abourehab},
  journal={Drug Design, Development and Therapy},
  pages={3071 - 3084}
Purpose This study is aimed at preparing and testing physicochemical, pharmacokinetic and levels of toxic metabolites of paracetamol and glucosamine solid dispersions intended for multiple deliveries via the parenteral or per oral route. Methods Solid dispersions were prepared using the spray drying technique at different molar ratios of paracetamol and glucosamine. Characterization of the solid dispersions was carried out using differential scanning calorimetry (DSC), Fourier transform… 
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