Glucosamine inhibits inducible nitric oxide synthesis.

@article{Meininger2000GlucosamineII,
  title={Glucosamine inhibits inducible nitric oxide synthesis.},
  author={Cynthia J. Meininger and Katherine A. Kelly and Hongbing Li and Tony E. Haynes and Ganlin Wu},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={279 1},
  pages={
          234-9
        }
}
  • Cynthia J. Meininger, Katherine A. Kelly, +2 authors Ganlin Wu
  • Published 2000
  • Biology, Medicine
  • Biochemical and biophysical research communications
  • Glucosamine is widely used in Europe for treatment of arthritis in humans. Based on recent findings that excess production of nitric oxide (NO) by inducible NO synthase (iNOS) mediates the pathogenesis of arthritis, we hypothesized that glucosamine may inhibit NO synthesis. To test this hypothesis, we used an in vivo rat model of lipopolysaccharide (LPS)-induced inflammation. Intravenous administration of d-glucosamine (0.5 mmol/kg) 6 h before, at the time of, and 6 h after intraperitoneal LPS… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 52 CITATIONS, ESTIMATED 56% COVERAGE

    Inhibitory action of glucosamine on platelet activation in guinea pigs

    VIEW 1 EXCERPT
    CITES BACKGROUND

    Attenuation of LPS-induced lung inflammation by glucosamine in rats.

    Acute O-GlcNAcylation prevents inflammation-induced vascular dysfunction.

    FILTER CITATIONS BY YEAR

    2002
    2019

    CITATION STATISTICS

    • 4 Highly Influenced Citations