Glucosamine inhibits epithelial-to-mesenchymal transition and migration of retinal pigment epithelium cells in culture and morphologic changes in a mouse model of proliferative vitreoretinopathy.

@article{Liang2011GlucosamineIE,
  title={Glucosamine inhibits epithelial-to-mesenchymal transition and migration of retinal pigment epithelium cells in culture and morphologic changes in a mouse model of proliferative vitreoretinopathy.},
  author={Chang-Min Liang and Ming-Cheng Tai and Yun-Hsiang Chang and Yi-Hao Chen and Ching-Long Chen and D Lu and Jiann-Torng Chen},
  journal={Acta ophthalmologica},
  year={2011},
  volume={89 6},
  pages={
          e505-14
        }
}
PURPOSE To explore the effect of glucosamine (GlcN) on transforming growth factor (TGF)-β signalling and several processes involved in proliferative vitreoretinopathy (PVR). METHODS We evaluated the surface levels of TGF-β receptor and its binding of TGF-β in ARPE-19 cells. Release of cytokines and collagen, and expression of signalling intermediates were quantified. Migration was qualitatively and quantitatively examined. The morphology of cells undergoing PVR in vitro and in a mouse PVR… CONTINUE READING

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