Glucosamine induces resistance to insulin-like growth factor I (IGF-I) and insulin in Hep G2 cell cultures: biological significance of IGF-I/insulin hybrid receptors.

@article{Sakai2003GlucosamineIR,
  title={Glucosamine induces resistance to insulin-like growth factor I (IGF-I) and insulin in Hep G2 cell cultures: biological significance of IGF-I/insulin hybrid receptors.},
  author={K. Sakai and D. Clemmons},
  journal={Endocrinology},
  year={2003},
  volume={144 6},
  pages={
          2388-95
        }
}
  • K. Sakai, D. Clemmons
  • Published 2003
  • Biology, Medicine
  • Endocrinology
  • IGF-I stimulates insulin-like actions directly through its receptor, and it also enhances sensitivity to insulin-mediated effects in vivo. These studies were undertaken to analyze the role of IGF-I, insulin, and insulin/IGF-I hybrid receptors (HRs) in mediating IGF-I and insulin signaling in cells that had been made insulin-resistant by treatment with glucosamine. Human HepG2 cells, which express IGF-I receptors, insulin receptors (IRs), and IGF-I/insulin HRs, were exposed to 20 mM glucosamine… CONTINUE READING
    Dysregulation of growth factor signaling in human hepatocellular carcinoma
    • 359
    • Open Access

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 28 REFERENCES