Glucosamine induces REDD1 to suppress insulin action in retinal Müller cells.

@article{Moore2016GlucosamineIR,
  title={Glucosamine induces REDD1 to suppress insulin action in retinal M{\"u}ller cells.},
  author={J. Moore and W. P. Miller and M. Dennis},
  journal={Cellular signalling},
  year={2016},
  volume={28 5},
  pages={
          384-390
        }
}
  • J. Moore, W. P. Miller, M. Dennis
  • Published 2016
  • Medicine, Biology
  • Cellular signalling
  • Resistance to insulin action is a key cause of diabetic complications, yet much remains unknown about the molecular mechanisms that contribute to the defect. Glucose-induced insulin resistance in peripheral tissues such as the retina is mediated in part by the hexosamine biosynthetic pathway (HBP). Glucosamine (GAM), a leading dietary supplement marketed to relieve the discomfort of osteoarthritis, is metabolized by the HBP, and in doing so bypasses the rate-limiting enzyme of the pathway. Thus… CONTINUE READING

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