Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production.

@article{Barzilai1996GlucosamineinducedIO,
  title={Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production.},
  author={Nir Barzilai and Meredith Hawkins and I v Angelov and Meizhu Hu and Luciano Rossetti},
  journal={Diabetes},
  year={1996},
  volume={45 10},
  pages={1329-35}
}
Although the kinetic characteristics of hepatic glucokinase (GK) suggest its potential role as the hepatic "glucose sensor," its impact on the regulation of in vivo hepatic glucose production (HGP) is still controversial. Since decreased GK activity has been linked to experimental and human diabetes, we examined whether a moderate and transient inhibition of GK activity diminishes the ability of hyperglycemia to suppress HGP. We first determined the concentration of the competitive inhibitor… CONTINUE READING

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