Glucosamine-induced &bgr;-cell Dysfunction: A Possible Involvement of Glucokinase or Glucose-transporter Type 2

  title={Glucosamine-induced &bgr;-cell Dysfunction: A Possible Involvement of Glucokinase or Glucose-transporter Type 2},
  author={H. Yoshikawa and Y. Tajiri and Y. Sako and T. Hashimato and F. Umeda and H. Nawata},
  • H. Yoshikawa, Y. Tajiri, +3 authors H. Nawata
  • Published 2002
  • Medicine, Biology
  • Pancreas
  • Introduction The mechanism for &bgr;-cell dysfunction induced by glucosamine has not yet fully been investigated previously. Aim To investigate the effects of glucosamine on insulin release or gene expression related to glucose metabolism in rat islets cultured with glucosamine for 24 hours. Methodology After islets were cultured with glucosamine or diazoxide, we measured glucose- or arginine-induced insulin release by using radioimmunoassay (RIA) and gene expressions by semiquantitative… CONTINUE READING
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