Glucosamine for pain in osteoarthritis: why do trial results differ?

@article{Vlad2007GlucosamineFP,
  title={Glucosamine for pain in osteoarthritis: why do trial results differ?},
  author={Steven C. Vlad and Michael P. LaValley and Timothy E. McAlindon and David T. Felson},
  journal={Arthritis and rheumatism},
  year={2007},
  volume={56 7},
  pages={
          2267-77
        }
}
OBJECTIVE Investigators in trials of glucosamine report a range of estimates for efficacy, making conclusions difficult. We undertook this study to identify factors that explain heterogeneity in trials of glucosamine. METHODS We searched for reports of trial results in Ovid Medline, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, and proceedings of scientific conferences. We selected reports of randomized, double-blind, placebo-controlled… 

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  • D. Felson
  • Medicine
    Nature Clinical Practice Rheumatology
  • 2008
TLDR
This study persuasively challenges claims that glucosamine acts as a disease modifier and that it alleviates pain and suggests that more publicly funded trials are needed, especially those of the Rottapharm glucosamines sulfate compound.
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