Glucosamine enhances paracetamol bioavailability by reducing its metabolism.

@article{Qinna2015GlucosamineEP,
  title={Glucosamine enhances paracetamol bioavailability by reducing its metabolism.},
  author={Nidal A Qinna and Maryam H Shubbar and Khalid Z. Matalka and Nawzat D. Al-Jbour and Mohammad A. Ghattas and Adnan A Badwan},
  journal={Journal of pharmaceutical sciences},
  year={2015},
  volume={104 1},
  pages={
          257-65
        }
}
Paracetamol has an extensive first-pass metabolism that highly affects its bioavailability (BA); thus, dose may be repeated several times a day in order to have longer efficacy. However, hepatotoxicity may arise because of paracetamol metabolism. Therefore, this project aimed to increase paracetamol BA in rats by glucosamine (GlcN). At GlcN-paracetamol racemic mixture ratio of 4:1 and paracetamol dose of 10 mg/kg, paracetamol area under the curve (AUC) and maximum concentration (Cmax ) were… 
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