Glucosamine enhances body weight gain and reduces insulin response in mice fed chow diet but mitigates obesity, insulin resistance and impaired glucose tolerance in mice high-fat diet.

@article{Hwang2015GlucosamineEB,
  title={Glucosamine enhances body weight gain and reduces insulin response in mice fed chow diet but mitigates obesity, insulin resistance and impaired glucose tolerance in mice high-fat diet.},
  author={Ji‐Sun Hwang and Jiwon Park and Moonsuk Nam and Hyeongjin Cho and Inn-Oc Han},
  journal={Metabolism: clinical and experimental},
  year={2015},
  volume={64 3},
  pages={
          368-79
        }
}
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44 References

Glucosamine attenuates increases of intraabdominal fat, serum leptin levels, and insulin resistance induced by a high-fat diet in rats.

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An increase in hexosamine metabolism in vivo inhibits glucose-induced insulin secretion, and reduces insulin stimulation of both glycolysis and glycogen synthesis, thereby mimicking in normal rats the major alterations due to glucose toxicity in diabetes.

In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats.

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