Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy.

@article{Anderson2005GlucosamineEI,
  title={Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy.},
  author={J. W. Anderson and R. Nicolosi and J. Borzelleca},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2005},
  volume={43 2},
  pages={
          187-201
        }
}
Glucosamine is widely used to relieve symptoms from osteoarthritis. [...] Key Method We reviewed clinical trial data for 3063 human subjects. Fasting plasma glucose values decreased slightly for subjects after oral glucosamine for approximately 66 weeks. There were no adverse effects of oral glucosamine administration on blood, urine or fecal parameters. Side effects were significantly less common with glucosamine than placebo or non-steroidal anti-inflammatory drugs (NSAID). In contrast to NSAID, no serious or…Expand
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TLDR
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Oral Glucosamine Effect on Blood Glucose and Insulin Levels in Patients With Non-Diabetic Osteoarthritis: A Double-Blind, Placebo-Controlled Clinical Trial.
TLDR
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TLDR
This study undertook this study to determine if glucosamine, taken at recommended doses for the treatment of osteoarthritis, had any detrimental effects on glucose metabolism. Expand
The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial.
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This study demonstrates that oral glucosamine supplementation does not result in clinically significant alterations in glucose metabolism in patients with type 2 diabetes mellitus. Expand
Effect of glucosamine supplementation on fasting and non-fasting plasma glucose and serum insulin concentrations in healthy individuals.
TLDR
The data suggests that glucosamine supplementation, with normal recommended dosages, does not cause glucose intolerance in healthy adults, however, this cannot be determined conclusively until further studies are conducted using alternative types of testing. Expand
Pharmacokinetics of glucosamine in man.
TLDR
The pharmacokinetics of glucosamines sulfate was investigated in 6 healthy male volunteers using 14C uniformly labelled glucosamine sulfate and administering it in single dose by intravenous, intramuscular or oral route and results show that after i.v. or i.m. administration the radioactivity due to glucose appears in plasma and is rapidly eliminated, but its concentration in plasma is about 5 times smaller than that after parenteral administration. Expand
Single dose pharmacokinetics and bioavailability of butyryl glucosamine in the rat.
TLDR
GLcNBu has rapid but low absorption and is widely distributed and efficiently cleared, which suggests a transport dependent absorption and the gut rather than liver is mainly responsible for the low bioavailability of GLc NBu. Expand
Glucosamine
TLDR
Improvement in the symptoms of osteoarthritis associated with the use of glucosamine has been observed in clinical trials; however, those trials have flaws in design and data analysis. Expand
Effects of oral glucosamine and chondroitin sulfate alone and in combination on the metabolism of SHR and SD rats
TLDR
It is concluded that glucosamine and chondroitin sulfate given alone or together do not produce insulin resistance or other related perturbations in two rat strains highly sensitive to sugar‐induced insulin resistance. Expand
Short-term glucosamine infusion does not affect insulin sensitivity in humans.
TLDR
The results do not support involvement of the hexosamine pathway in the regulation of insulin sensitivity in humans, at least not in the short-term setting. Expand
Efficacy and safety of intramuscular glucosamine sulfate in osteoarthritis of the knee. A randomised, placebo-controlled, double-blind study.
TLDR
Assessment of the efficacy and safety of glucosamine sulfate intramuscularly given on the same parameters found that when orally given, it is more effective than placebo and at least as effective as non-steroidal anti-inflammatory drugs in relieving osteoarthritis symptoms. Expand
Glucosamine sulfate in osteoarthritis of the knee.
TLDR
It is concluded that glucosamine sulfate may be a safe and effective symptomatic Slow Acting Drug for OA. Expand
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