Glucosamine and glucose induce insulin resistance by different mechanisms in rat skeletal muscle.

@article{Han2003GlucosamineAG,
  title={Glucosamine and glucose induce insulin resistance by different mechanisms in rat skeletal muscle.},
  author={Dong-Ho Han and May M. Chen and John O. Holloszy},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2003},
  volume={285 6},
  pages={
          E1267-72
        }
}
It has been hypothesized that glucose-induced insulin resistance is mediated by accumulation of UDP-N-acetylhexosamines (UDP-HexNAcs). In a previous study on rat epitrochlearis muscles incubated with high concentrations of glucose and insulin (Kawanaka K, D-H Han, J Gao, LA Nolte, and JO Holloszy. J Biol Chem 276: 20101-20107, 2001), we found that insulin resistance developed even when the increase in UDP-Hex-NAcs was prevented. Furthermore, actinomycin D completely prevented glucose-induced… Expand
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