Glucosamine and chondroitin sulphate did not improve pain in osteoarthritis of the knee

@article{Baime2006GlucosamineAC,
  title={Glucosamine and chondroitin sulphate did not improve pain in osteoarthritis of the knee},
  author={Michael J. Baime},
  journal={Evidence Based Medicine},
  year={2006},
  volume={11},
  pages={115 - 115}
}
  • M. Baime
  • Published 28 July 2006
  • Medicine
  • Evidence Based Medicine
Source Citation Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006;354:795-808. 16495392 
Importance of pharmaceutical composition and evidence from clinical trials and pharmacological studies in determining effectiveness of chondroitin sulphate and other glycosaminoglycans: a critique
TLDR
High quality and fully standardized CS (Condrosulf) has become available and its effects have been studied in large‐scale osteoarthritis trials, which are discussed here.
Effects of chondroitin sulfate and glucosamine in adult patients with Kaschin–Beck disease
TLDR
Knee joint space of the experimental group narrowed slowly compared to the control group, suggesting chondroitin sulfate and glucosamine might play a protective role in preserving articular cartilage and provide evidence for therapeutic drugs in adult patients with KBD.
Importance of pharmaceutical composition and evidence from clinical trials and pharmacological studies in determining effectiveness of chondroitin sulphate and other glycosaminoglycans: a critique.
  • K. Rainsford
  • Medicine
    The Journal of pharmacy and pharmacology
  • 2009
TLDR
There may be potential value of CS in reducing the dependence on intake of NSAIDs and analgesics in patients with osteoarthritis, while at the same time having favourable safety.

References

SHOWING 1-3 OF 3 REFERENCES
Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.
TLDR
Exploratory analyses suggest that the combination of glucosamine and chondroitin sulfate may be effective in the subgroup of patients with moderate-to-severe knee pain, and the efficacy and safety of these treatments as a treatment for knee pain from osteoarthritis are evaluated.
Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis.
TLDR
Evaluation of benefit of glucosamine and chondroitin preparations for OA symptoms using meta-analysis combined with systematic quality assessment of clinical trials of these preparations in knee and/or hip OA suggests some degree of efficacy appears probable for these preparations.
Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis.
TLDR
This study demonstrates the structural efficacy of glucosamine and indistinguishable symptomatic efficacies for both compounds in knee osteoarthritis and further studies are needed to investigate the relationship among time, dose, patient baseline characteristics, and structural efficacy for an accurate, disease-modifying characterization of these 2 compounds.