Glucosamine and chondroitin sulfate regulate gene expression and synthesis of nitric oxide and prostaglandin E(2) in articular cartilage explants.

@article{Chan2005GlucosamineAC,
  title={Glucosamine and chondroitin sulfate regulate gene expression and synthesis of nitric oxide and prostaglandin E(2) in articular cartilage explants.},
  author={P. S. Chan and J. P. Caron and G. J. M. Rosa and M. Orth},
  journal={Osteoarthritis and cartilage},
  year={2005},
  volume={13 5},
  pages={
          387-94
        }
}
  • P. S. Chan, J. P. Caron, +1 author M. Orth
  • Published 2005
  • Medicine
  • Osteoarthritis and cartilage
  • OBJECTIVE Glucosamine (GLN) and chondroitin sulfate (CS) are widely used to alleviate symptoms of osteoarthritis (OA). However, the mechanism(s) of action of these nutraceuticals remains unresolved. In the present study, we determined the effect of physiologically relevant concentrations of GLN and CS on gene expression and synthesis of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) in cytokine-stimulated articular cartilage explants. METHODS Using bovine articular cartilage explants in… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 136 CITATIONS, ESTIMATED 62% COVERAGE

    Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1β

    VIEW 2 EXCERPTS
    CITES BACKGROUND & RESULTS

    FILTER CITATIONS BY YEAR

    2005
    2020

    CITATION STATISTICS

    • 1 Highly Influenced Citations

    • Averaged 7 Citations per year from 2018 through 2020

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 68 REFERENCES

    Nitric oxide activates metalloprotease enzymes in articular cartilage.