Glucosamine and chondroitin sulfate: biological response modifiers of chondrocytes under simulated conditions of joint stress.

@article{Lippiello2003GlucosamineAC,
  title={Glucosamine and chondroitin sulfate: biological response modifiers of chondrocytes under simulated conditions of joint stress.},
  author={Louis Lippiello},
  journal={Osteoarthritis and cartilage},
  year={2003},
  volume={11 5},
  pages={335-42}
}
OBJECTIVE To test the hypothesis that chondrocytes are more responsive to the chondroprotective agents, glucosamine (glcN) and chondroitin sulfate (CS), under in vitro conditions simulating in vivo joint stress. DESIGN Synthetic and anticatabolic activities of bovine articular cartilage were assayed using 35-sulfate labeling and assaying the specific activity of glycosaminoglycans (GAGs) under the conditions of enzyme-induced matrix depletion, heat stress, mechanical compression and cytokine… CONTINUE READING

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