Glucosamine and Chondroitin Sulfate as Therapeutic Agents for Knee and Hip Osteoarthritis

  title={Glucosamine and Chondroitin Sulfate as Therapeutic Agents for Knee and Hip Osteoarthritis},
  author={Olivier Bruy{\`e}re and Jean-Yves Reginster},
  journal={Drugs \& Aging},
Osteoarthritis (OA), the most common form of arthritis, is a public health problem throughout the world. Several entities have been carefully investigated for the symptomatic and structural management of OA. This review evaluates published studies of the effect of glucosamine salts and chondroitin sulfate preparations on the progression of knee or hip OA.Despite multiple double-blind, controlled clinical trials of the use of glucosamine and chondroitin sulfate in OA, controversy regarding the… 
Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT
Over 2 years, no treatment achieved a clinically important difference in WOMAC pain or function as compared with placebo, however, glucosamine and celecoxib showed beneficial but not significant trends.
Glucosamine Sulfate and Chondroitin Sulfate for the Treatment of Osteoarthritis
There is some evidence that GS and CS may interfere with structural progression of OA, and the meta-analyses have shown that GS (but not glucosamine hydrochloride) and CS have small-to-moderate symptomatic efficacy in OA.
The Efficacy of Topical Glucosamine Sulfate-Chondroitin Sulfate in Knee Osteoarthritis Treated With Physical Therapy: A Randomized, Double-Blind, Placebo-Controlled Study
It was shown that topical glucosamine treatment combined with physical therapy in patients with knee OA had no superiority over placebo.
The effect of oral Glucosamine Chondroitin sulfate in the management of knee osteoarthritis
The study concludes that glucoseamine chondroitine sulfate is effective in both symptomatic and functional improvement of osteoarthritis whatever the severity.
Chondroitin sulphate for symptomatic osteoarthritis: critical appraisal of meta-analyses
Data provided by meta-analyses indicate that CS has a slight to moderate efficacy in the symptomatic treatment of OA, with an excellent safety profile.
Efficiency of Glucosamine Sulphate and Chondroitin Sulphate Сombination in Osteoarthritis Treatment from Evidence-Based Medicine Positions
The results of clinical studies, as well as a deeper understanding of the differences in the pharmacokinetics and properties of molecules of different chondroprotectors have aroused scientific and practical interest in approaches to the treatment of joint diseases using a combination of chondroitin sulfate and glucosamine sulfate.
Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis
This is the first clinical trial in which glucosamine was given in combination with omega-3 fatty acids to patients with OA and both products have been demonstrated to be very safe in long-term treatment over 26 weeks.
Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids
  • J. Jerosch
  • Biology, Medicine
    International journal of rheumatology
  • 2011
Chondroprotective action can be explained by a dual mechanism: as basic components of cartilage and synovial fluid, they stimulate the anabolic process of the cartilage metabolism, and their anti-inflammatory action can delay many inflammation-induced catabolic processes in thecartilage.
Effect of 12 months treatment with chondroitin sulfate on cartilage volume in knee osteoarthritis patients: a randomized, double-blind, placebo-controlled pilot study using MRI
The usefulness of quantitative and qualitative MRI as a sensitive tool to assess a structure modifying drugs in knee osteoarthritis is confirmed, and the difference in the evolution of cartilage volume between the two groups could reflect a structure modify effect of Structum®.


Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.
Exploratory analyses suggest that the combination of glucosamine and chondroitin sulfate may be effective in the subgroup of patients with moderate-to-severe knee pain, and the efficacy and safety of these treatments as a treatment for knee pain from osteoarthritis are evaluated.
Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis.
Evaluation of benefit of glucosamine and chondroitin preparations for OA symptoms using meta-analysis combined with systematic quality assessment of clinical trials of these preparations in knee and/or hip OA suggests some degree of efficacy appears probable for these preparations.
Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis.
This study demonstrates the structural efficacy of glucosamine and indistinguishable symptomatic efficacies for both compounds in knee osteoarthritis and further studies are needed to investigate the relationship among time, dose, patient baseline characteristics, and structural efficacy for an accurate, disease-modifying characterization of these 2 compounds.
Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study.
Long-term treatment with glucosamine sulfate retarded the progression of knee osteoarthritis, possibly determining disease modification.
Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.
Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator.
The findings of this study indicate that glucosamine sulfate at the oral once-daily dosage of 1,500 mg is more effective than placebo in treating knee OA symptoms.
Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: a randomized, controlled trial.
While there was no significant symptomatic effect in this study, long-term treatment with CS may retard radiographic progression in patients with OA of the knee, but the clinical relevance of the observed structural results has to be further evaluated, and further studies are needed to confirm the structural effects of CS.
Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee.
There was no significant difference in pain reduction between the glucosamine hydrochloride and placebo groups as measured by WOMAC, but the secondary endpoints of cumulative pain reduction as measures by daily diary and knee examination were favorable, suggesting that glucosamines hydrochlorides benefits some patients with knee OA.