Glucosamine Protects Rat Bone Marrow Cells Against Cisplatin-Induced Genotoxicity and Cytotoxicity.

  title={Glucosamine Protects Rat Bone Marrow Cells Against Cisplatin-Induced Genotoxicity and Cytotoxicity.},
  author={Mohsen Cheki and Salman Jafari and Masoud Najafi and Aziz Mahmoudzadeh},
  journal={Anti-cancer agents in medicinal chemistry},
BACKGROUND AND OBJECTIVE Glucosamine is a widely prescribed dietary supplement used in the treatment of osteoarthritis. In present study, the chemoprotectant ability of glucosamine was evaluated against cisplatin-induced genotoxicity and cytotoxicity in rat bone marrow cells. METHODS Glucosamine was orally administrated to rats at doses of 75 and 150 mg/kg body weight for seven consecutive days. On the seventh day, rats were treated with a single injection of cisplatin (5 mg/kg, i.p.) at 1h… Expand
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