Glucosamine Modulates T Cell Differentiation through Down-regulating N-Linked Glycosylation of CD25*

  title={Glucosamine Modulates T Cell Differentiation through Down-regulating N-Linked Glycosylation of CD25*},
  author={Ming-Wei Chien and Ming-Hong Lin and Shing-Hwa Huang and Shin-Huei Fu and Chao-Yuan Hsu and B Linju Yen and Jiann-Torng Chen and Deh Ming Chang and Huey-Kang Sytwu},
  journal={The Journal of Biological Chemistry},
  pages={29329 - 29344}
Background: Glucosamine is an amino sugar that has immunoregulatory effects on T cell-mediated diseases. Results: Glucosamine inhibits Th1, Th2, iTreg cells, but promotes Th17 cell development through interference with N-glycosylation of CD25. Conclusion: Glucosamine modulates T cell differentiation in vivo and subsequently influences the progression and severity of autoimmune diseases. Significance: Glucosamine-mediated modulation of CD25 glycosylation can be beneficial to controlling… 

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