Glucosamine Long-Term Treatment and the Progression of Knee Osteoarthritis: Systematic Review of Randomized Controlled Trials

@article{Poolsup2005GlucosamineLT,
  title={Glucosamine Long-Term Treatment and the Progression of Knee Osteoarthritis: Systematic Review of Randomized Controlled Trials},
  author={Nalinee Poolsup and Chutamanee Suthisisang and Patchareeya Channark and Wararat Kittikulsuth},
  journal={Annals of Pharmacotherapy},
  year={2005},
  volume={39},
  pages={1080 - 1087}
}
OBJECTIVE: To investigate the structural and symptomatic efficacy and safety of glucosamine in knee osteoarthritis (OA). DATA SOURCES: Clinical trials of glucosamine were identified through electronic searches (MEDLINE, EMBASE, BIOSIS, EMB review, the Cochrane Library) using the key words glucosamine, osteoarthritis, degenerative joint disease, degenerative arthritis, osteoarthrosis, gonarthrosis, knee, disease progression, and clinical trial. The bibliographic databases were searched from… 
Treatment of primary and secondary osteoarthritis of the knee.
TLDR
The three interventions reviewed in this report are widely used in the treatment of OA of the knee, yet the best available evidence does not clearly demonstrate clinical benefit.
Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis
TLDR
Compared with placebo, glucosamine, chondroitin, and their combination do not reduce joint pain or have an impact on narrowing of joint space and health authorities and health insurers should not cover the costs.
Chondroprotection and the Prevention of Osteoarthritis Progression of the Knee
TLDR
For patients with or at risk for osteoarthritis, the use of glucosamine and chondroitin sulfate may serve as a nonoperative means to protect joint cartilage and delay osteoartritis progression.
Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT
TLDR
Over 2 years, no treatment achieved a clinically important difference in WOMAC pain or function as compared with placebo, however, glucosamine and celecoxib showed beneficial but not significant trends.
Osteoarthritis of the knee
TLDR
The review found that exercise regimens significantly improved physical health and the clinical impact of osteoarthritis compared with control conditions and there was considerable heterogeneity in the study design and in the interventions themselves.
A natural mineral supplement provides relief from knee osteoarthritis symptoms: a randomized controlled pilot trial
TLDR
It is suggested that a multi mineral supplement (Aquamin) may reduce the pain and stiffness of osteoarthritis of the knee over 12 weeks of treatment and warrants further study.
Glucosamine as a Treatment for Osteoarthritis: What If It’s True?
TLDR
Data confirm animal studies demonstrating a protective effect of GlcN against cancer and cardiovascular diseases due to modulation of the O-GlcNAcylation pathway and suggest thatglcN may be effective in the primary prevention of OA in sportsmen.
How effective is glucosamine in the treatment of osteoarthritis compared to placebo and chondroitin?: A review of the best evidence
TLDR
There are a wide range of management options that have varying levels of evidence for their efficacy, including exercise, ambulatory aids, weight loss, pharmaceuticals, surgery, intra-articular injections and complementary medicines (CAM).
...
...

References

SHOWING 1-10 OF 50 REFERENCES
Glucosamine therapy for treating osteoarthritis.
TLDR
The results are not uniformly positive, and the reasons for this remain unexplained, but glucosamine was superior to placebo in the treatment of pain and functional impairment resulting from symptomatic OA.
Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis.
TLDR
This study demonstrates the structural efficacy of glucosamine and indistinguishable symptomatic efficacies for both compounds in knee osteoarthritis and further studies are needed to investigate the relationship among time, dose, patient baseline characteristics, and structural efficacy for an accurate, disease-modifying characterization of these 2 compounds.
Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis.
TLDR
Evaluation of benefit of glucosamine and chondroitin preparations for OA symptoms using meta-analysis combined with systematic quality assessment of clinical trials of these preparations in knee and/or hip OA suggests some degree of efficacy appears probable for these preparations.
Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study.
TLDR
Long-term treatment with glucosamine sulfate retarded the progression of knee osteoarthritis, possibly determining disease modification.
Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies
TLDR
It is demonstrated for the first time that a pharmacological intervention for OA has a disease-modifying effect in this particular population, the most frequently affected by knee OA.
A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee.
TLDR
As a symptom modifier in OA patients with a wide range of pain severities, glucosamine sulphate was no more effective than placebo.
Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee.
TLDR
There was no significant difference in pain reduction between the glucosamine hydrochloride and placebo groups as measured by WOMAC, but the secondary endpoints of cumulative pain reduction as measures by daily diary and knee examination were favorable, suggesting that glucosamines hydrochlorides benefits some patients with knee OA.
...
...