Glucosamine Hydrochloride but Not Chondroitin Sulfate Prevents Cartilage Degradation and Inflammation Induced by Interleukin-1α in Bovine Cartilage Explants

@article{BascoulColombo2016GlucosamineHB,
  title={Glucosamine Hydrochloride but Not Chondroitin Sulfate Prevents Cartilage Degradation and Inflammation Induced by Interleukin-1α in Bovine Cartilage Explants},
  author={C{\'e}cile Bascoul-Colombo and Iveta Garaiov{\'a} and Sue F. Plummer and John L Harwood and Bruce Caterson and Clare Elizabeth Hughes},
  journal={Cartilage},
  year={2016},
  volume={7},
  pages={70 - 81}
}
  • Cécile Bascoul-Colombo, Iveta Garaiová, +3 authors Clare Elizabeth Hughes
  • Published 2016
  • Medicine
  • Cartilage
  • Objective Glucosamine hydrochloride (GH) and chondroitin sulfate (CS) are commonly used for the treatment of osteoarthritis (OA). The aim of this study was to assess their effects, alone and in combination, on preventing aggrecan degradation and inflammation in an in vitro model of OA. Design To test the effects of GH and/or CS as a preventative treatment, cartilage explants were pretreated with the compound(s) using concentrations that showed no detrimental effect on chondrocyte viability… CONTINUE READING

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