Glucosamine HCl as a new carrier for improved dissolution behaviour: effect of grinding.

@article{AlHamidi2010GlucosamineHA,
  title={Glucosamine HCl as a new carrier for improved dissolution behaviour: effect of grinding.},
  author={Hiba Al-Hamidi and Alison A Edwards and Mohammad Amin Mohammad and Ali Nokhodchi},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2010},
  volume={81 1},
  pages={
          96-109
        }
}
The co-grinding technique is one of the most effective methods for improving the dissolution rate of poorly water-soluble drugs and it is superior to other approaches from an economical as well as an environmental stand point, as the technique does not require any toxic organic solvents. The present work is an attempt to use d-glucosamine HCl (G-HCl) as a potential excipient to improve dissolution rate of carbamazepine (CBZ) from physical mixtures and co-grinding formulations. The effect of… Expand
Dissolution and solid state behaviours of carbamazepine-gluconolactone solid dispersion powders: The potential use of gluconolactone as dissolution enhancer
Solid dispersions are one of the most effective methods for improving the dissolution rate of poorly water-soluble drugs; however, this is reliant on the selection of a suitable carrier and solvent.Expand
An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine
Abstract One of strategies adopted to improve the dissolution rates of poorly soluble drugs is by co-grinding the drug with a hydrophilic carrier. However, the introduction of mechanical forcesExpand
Increased dissolution rates of carbamazepine – gluconolactone binary blends processed by hot melt extrusion
TLDR
A new hydrophilic carrier, d-gluconolactone (GNL), was extruded with CBZ at various molar ratios to produce granules by using hot melt extrusion (HME) processing to enhance the dissolution rate of Carbamazepine. Expand
Co-amorphous drug systems of carbamazepine: intrinsic dissolution rate improvements
Co-amorphous systems is one of the attractive strategies used to enhance the dissolution rates of poorly soluble drugs. This strategy has an additional advantage as it has the ability to overcomeExpand
Evaluation of solubility and dissolution profile of itraconazole after cogrinding with various hydrophilic carriers
The aim of this study was to improve the dissolution properties of very poorly soluble widely used antifungal drug, Itraconazole. Itraconazole were coground with cross povidone, poloxamer, polyvinylExpand
Dissolution Enhancement of Atorvastatin Calcium by Cocrystallization
TLDR
Cocrystallization significantly improved the solubility and dissolution of the poorly soluble drug atorvastatin calcium by cocrystallization, in comparison to the untreated ATC. Expand
Comparing various techniques to produce micro/nanoparticles for enhancing the dissolution of celecoxib containing PVP.
TLDR
It can be concluded that the method of preparation of CLX micro/nanoparticles had a big impact on the dissolution rate when the concentration of PVP was low, and at high PVP concentration all methods used to prepare engineered CLX particles showed better dissolution with no significant differences in their dissolution efficiency. Expand
Preparation and physicochemical characterization of binary and ternary ground mixtures of carvedilol with PVP and SLS aimed to improve the drug dissolution
TLDR
According to the results, co-grinding in the presence of PVP and SLS significantly increased CA dissolution rate, and the solubility of this formulation was about 10 times higher compared to that of the intact CA. Expand
Promising dissolution enhancement effect of soluplus on crystallized celecoxib obtained through antisolvent precipitation and high pressure homogenization techniques.
TLDR
The results showed that celecoxib nanoparticle can be obtained when soluplus was added to the crystallization medium, and DSC and XRPD proved that samples obtained via HPH technique are more crystalline than the samples obtained through only antisolvent crystallization technique. Expand
Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions.
This work explores the use of both spray drying and d-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic chargesExpand
...
1
2
3
...

References

SHOWING 1-10 OF 39 REFERENCES
To enhance dissolution rate of poorly water-soluble drugs: glucosamine hydrochloride as a potential carrier in solid dispersion formulations.
TLDR
It has been shown that the use of G-HCl in solid dispersion formulations can significantly enhance the dissolution rate of poorly water-soluble drugs such as carbamazepine. Expand
Cogrinding as an approach to enhance dissolution rate of a poorly water-soluble drug (gliclazide)
Gliclazide is practically insoluble in water. In order to improve the drug dissolution rate, cogrinding method was used as an approach to prepare gliclazide coground/solid dispersions (SDs) in theExpand
Improvement of dissolution characteristics and bioavailability of poorly water-soluble drugs by novel cogrinding method using water-soluble polymer
Abstract A novel cogrinding method for improving dissolution characteristics of poorly water-soluble drugs was developed. A coground mixture of nifedipine (NP)-polyethylene glycolExpand
The use of ordered mixtures for improving the dissolution rate of low solubility compounds& *
TLDR
It was concluded that the rate limiting step in the dissolution of griseofulvin as the raw material is the penetration of the dissolution medium into the agglomerates. Expand
Surfactant effects upon dissolution patterns of carbamazepine immediate release tablet
TLDR
The results clearly demonstrated that the dissolution rate of carbamazepine and duration of its dissolution test could be tailored by optimizing the amount of sodium lauryl sulfate in a dissolution medium. Expand
Effects of grinding on the physicochemical properties of cephalexin powder
The effects of grinding on the physicochemical properties of cephalexin (CEX) were studied by means of water content measurements, differential thermal analysis (DTA), differential scanningExpand
Processing of carbamazepine-PEG 4000 solid dispersions with supercritical carbon dioxide: preparation, characterisation, and in vitro dissolution.
TLDR
The dramatic reduction of the dimensions and the better crystal shape, together with the presence of the hydrophilic polymer determined a remarkable enhancement of the in vitro drug dissolution rate. Expand
Physicochemical properties and bioavailability of carbamazepine polymorphs and dihydrate.
TLDR
Findings suggested that most crystalline powder of each form administered at the low dose was rapidly dissolved in gastrointestinal (GI) fluid. Expand
Dissolution and mechanical behaviors of recrystallized carbamazepine from alcohol solution in the presence of additives
Carbamazepine (CBZ) crystals were grown from pure ethanol solutions containing various additives (PEG 4000, PVP K30 or Tween 80). Physical characteristics of the crystals were studied for theExpand
The concept of dissolution efficiency
  • K. A. Khan
  • Chemistry, Medicine
  • The Journal of pharmacy and pharmacology
  • 1975
TLDR
A further parameter suitable for the evaluation of in vitro dissolution has been suggested by Khan & Rhodes (1972), who introduced the idea of Dissolution Efficiency, defined as the area under the dissolution curve up to a certain time expressed as a percentage of the area of the rectangle described by 100% dissolutionin the sametime. Expand
...
1
2
3
4
...