Glucosamine HCl as a new carrier for improved dissolution behaviour: effect of grinding.

  title={Glucosamine HCl as a new carrier for improved dissolution behaviour: effect of grinding.},
  author={Hiba Al-Hamidi and Alison A Edwards and Mohammad Amin Mohammad and Ali Nokhodchi},
  journal={Colloids and surfaces. B, Biointerfaces},
  volume={81 1},
The co-grinding technique is one of the most effective methods for improving the dissolution rate of poorly water-soluble drugs and it is superior to other approaches from an economical as well as an environmental stand point, as the technique does not require any toxic organic solvents. The present work is an attempt to use d-glucosamine HCl (G-HCl) as a potential excipient to improve dissolution rate of carbamazepine (CBZ) from physical mixtures and co-grinding formulations. The effect of… Expand
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The concept of dissolution efficiency
  • K. A. Khan
  • Chemistry, Medicine
  • The Journal of pharmacy and pharmacology
  • 1975
A further parameter suitable for the evaluation of in vitro dissolution has been suggested by Khan & Rhodes (1972), who introduced the idea of Dissolution Efficiency, defined as the area under the dissolution curve up to a certain time expressed as a percentage of the area of the rectangle described by 100% dissolutionin the sametime. Expand