Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.

@article{Clegg2006GlucosamineCS,
  title={Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.},
  author={Daniel O. Clegg and Domenic J. Reda and Crystal L Harris and Marguerite A Klein and James R. O'Dell and Michele M Hooper and John Douglas Bradley and Clifton O Bingham and Michael H. Weisman and Christopher G. Jackson and Nancy E. Lane and John J. Cush and Larry Moreland and Harold R. Schumacher and Chester V. Oddis and Frederick J Wolfe and Jerry A. Molitor and David Yocum and Thomas J. Schnitzer and Daniel e. Furst and Allen Dale Sawitzke and Helen Shi and Kenneth D. Brandt and Roland W. Moskowitz and Helen J. Williams},
  journal={The New England journal of medicine},
  year={2006},
  volume={354 8},
  pages={795-808}
}
BACKGROUND Glucosamine and chondroitin sulfate are used to treat osteoarthritis. The multicenter, double-blind, placebo- and celecoxib-controlled Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) evaluated their efficacy and safety as a treatment for knee pain from osteoarthritis. METHODS We randomly assigned 1583 patients with symptomatic knee osteoarthritis to receive 1500 mg of glucosamine daily, 1200 mg of chondroitin sulfate daily, both glucosamine and chondroitin sulfate, 200… CONTINUE READING
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Efficacy and tolerability of lumiracoxib 100 mg once daily in knee osteoarthritis : a 13 - week , randomized , double - blind study vs . placebo and celecoxib

  • GW Cannon, Caldwell, P Holt
  • Curr Med Res Opin
  • 2005

Glucosamine therapy for treating osteoarthritis

  • DS AdebowaleAOCox, Z Liang
  • Cochrane Database Syst Rev
  • 2005

Effectiveness of glucosamine for symptoms of knee osteoarthritis : results from an Internet - based randomized double - blind controlled trial

  • B Mazieres, G Loyau, CJ Menkes
  • Am J Med
  • 2004

Randomized , double - blind , placebo - controlled glucosamine discontinuation trial in knee osteoarthritis

  • T McAlindon, M Formica, M LaValley, M Lehmer, K Kabbara
  • Arthritis Rheum
  • 2004

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