Glucoreceptor mechanisms and the control of insulin release and biosynthesis

@article{Ashcroft1980GlucoreceptorMA,
  title={Glucoreceptor mechanisms and the control of insulin release and biosynthesis},
  author={Stephen J. H. Ashcroft},
  journal={Diabetologia},
  year={1980},
  volume={18},
  pages={5-15}
}
The models proposed for the means whereby the B-cell recognises glucose and related compounds as signals for insulin release and biosynthesis are discussed. The observed correlations between rates of metabolism and insulin release and biosynthesis are consistent with the substrate-site hypothesis. For glucose itself, the enzymes catalysing the phosphorylation of the sugar provide an explanation for the major characteristics of the islet responses, but for N-acetylglucosamine evidence is… CONTINUE READING

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