Glucoreceptor mechanisms and the control of insulin release and biosynthesis

  title={Glucoreceptor mechanisms and the control of insulin release and biosynthesis},
  author={Stephen J. H. Ashcroft},
The models proposed for the means whereby the B-cell recognises glucose and related compounds as signals for insulin release and biosynthesis are discussed. The observed correlations between rates of metabolism and insulin release and biosynthesis are consistent with the substrate-site hypothesis. For glucose itself, the enzymes catalysing the phosphorylation of the sugar provide an explanation for the major characteristics of the islet responses, but for N-acetylglucosamine evidence is… CONTINUE READING


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/ 3Cell recognition of steroisomers of D - glucose

  • H AshcroftSJ, M Lowry
  • Diabetologia
  • 1979

Effect of methylene blue on pyrdine nucleotides and insulin secretion of rat pancreatic islets

  • EgglestonLV VeechRL, KrebsHA
  • Diabetologia
  • 1979

Insulin release : the fuel hypothesis

  • KawazuS SenerA, BoscheroAC HuttonJC, DevisG, MalaisseWJ HerchuelzA
  • Metabolism
  • 1979

Presence and possible role of calcium - dependent regulator ( calmodulin ) in rat islets of Langerhans

  • WeissB LevinRM
  • FEBS Lett
  • 1979

The stimulussecretion coupling of glucoseinduced insulin release . The links between metabolic and cationic events

  • J MalaisseW, A Sener, HerchuelzA, JC Hutton
  • Diabetologia
  • 1979

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