Gluconeogenesis in the amphibian retina. Lactate is preferred to glutamate as the gluconeogenic precursor.

@article{Goldman1988GluconeogenesisIT,
  title={Gluconeogenesis in the amphibian retina. Lactate is preferred to glutamate as the gluconeogenic precursor.},
  author={Stephen S. Goldman},
  journal={The Biochemical journal},
  year={1988},
  volume={254 2},
  pages={359-65}
}
The capacity for gluconeogenesis in the isolated amphibian retina was found to be approx. 70-fold greater with lactate than with glutamate as the gluconeogenic precursor, 1426 versus 21 pmol of glucose incorporated into glycogen/h per mg of protein. It was also found that 11-15% of the glucosyl units in glycogen are derived from C3 metabolites of the glycolytic pathway, suggesting that lactate is recycled within the retina. In concert with these metabolic observations, a full complement of the… CONTINUE READING