Gluconeogenesis in rat hepatocytes from monomethyl succinate and other esters.

@article{Rognstad1984GluconeogenesisIR,
  title={Gluconeogenesis in rat hepatocytes from monomethyl succinate and other esters.},
  author={Robert Rognstad},
  journal={Archives of biochemistry and biophysics},
  year={1984},
  volume={230 2},
  pages={
          605-9
        }
}
Although little glucose is formed from succinate in rat hepatocytes, the rate of gluconeogenesis from monomethyl succinate approaches that from L-lactate. Dimethyl succinate is as good as monomethyl succinate at 5 mM, but not at 20 mM. Monoethyl fumarate and 4-methyl malate are only fair glucogenic substrates, but 1-methyl malate is another good substrate at high concentrations. The esters are apparently taken up either directly through the cell membrane, or by monocarboxylate transporters, and… CONTINUE READING
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