Gluconeogenesis from glycine and serine in the rat.

@article{Nadkarni1960GluconeogenesisFG,
  title={Gluconeogenesis from glycine and serine in the rat.},
  author={G. B. Nadkarni and B. Friedmann and Sidney Weinhouse},
  journal={The Journal of biological chemistry},
  year={1960},
  volume={235},
  pages={
          420-5
        }
}
Although it is assumed that amino acids constitute the main source of glucose production in animals, relatively little modern work has been done on the magnitude of gluconeogenesis from amino acids or on the factors which might influence this process. Studies conducted in early years were based principally on the experimental techniques of measuring glucose excretion in phlorizinized or depancreatized animals (1) or of measuring increases of liver glycogen in fasting animals (2, 3). Such early… Expand
Gluconeogenesis from serine in rabbit hepatocytes.
TLDR
It has been concluded from the data that, probably in contrast to the rat, the major pathway for the entrance of L-serine into gluconeogenesis in rabbit hepatocytes is through the pathway initiated by L-Serine: pyruvate aminotransferase and that L-lactate is an important participant by generating cytoplasmic reducing equivalents (NADH). Expand
Gluconeogensis in vivo from glycine in x-irradiated rats.
  • G. B. Nadkarni, L. D. Deshpande
  • Chemistry, Medicine
  • International journal of radiation biology and related studies in physics, chemistry, and medicine
  • 1968
TLDR
Findings did not suggest an enhancement in the net synthesis of the sugar in x-irradiated rats, although the incorporation of radioactivity in blood sugar and liver glycogen was high at all time-intervals studied in cortisone-treated rats, showing enhanced gluconeogenesis. Expand
Enzymes of glucose formation and turnover in x-irradiated rats.
  • L. D. Deshpande, G. B. Nadkarni
  • Chemistry, Medicine
  • International journal of radiation biology and related studies in physics, chemistry, and medicine
  • 1968
TLDR
Analysis of liver enzymes involved in deamination of amino acids, gluconeogenesis and the hepatic turnover of glucose suggested that variations in the enzyme activities could be due to physiological adaptations following a flux of substrates. Expand
Control of gluconeogenesis in liver. IV. Differential effects of fatty acids and glucagon on ketogenesis and gluconeogenesis in the perfused rat liver.
TLDR
It is concluded that fatty acids probably do not play a physiological role in the rapid regulation of hepatic gluc oneogenesis, and that glucagon does not stimulate gluconeogenesis by activating hepatic lipolysis. Expand
Effect of insulin on gluconeogenesis from glycine-2-C.
Abstract Effects of insulin on gluconeogenesis in vivo from glycine have been studied in nondiabetic and alloxan-diabetic rats by following the incorporation of radioactivity of injectedExpand
Control of gluconeogenesis in liver. V. Effects of fasting, diabetes, and glucagon on lactate and endogenous metabolism in the perfused rat liver.
TLDR
It is concluded that changes in the disposition of substrate (pyruvate or fatty acid) within the liver may be as important as changes in substrate supply in the alterations in gluconeogenesis and ketogenesis during fasting and diabetes. Expand
Hormonal regulation of phosphoenolpyruvate carboxykinase activity in liver and kidney of adult animals and formation of this enzyme in developing rabbit liver.
TLDR
Variations in PEPCK-ase activity in rabbit liver have been followed for 30 days of their postnatal development and within the first postnatal day the enzyme activity rose abruptly to values higher than those of adult animals. Expand
Analysis of a characteristic alteration of glycogen in the liver of alloxan diabetic rat by fasting.
  • T. Komatsu
  • Medicine
  • Nagoya journal of medical science
  • 1977
TLDR
There was a positive correlation between the blood glucose level and the liver glycogen level in fasted diabetic condition, and 14C-glucose in the blood converted from (2.l4C] lactate was more in alloxan-treated rats, it was attributed to delayed disappearance of glucose from the blood stream. Expand
Pyruvate metabolism in mammalian liver.
TLDR
An inverse correlation exists between the percentage of labeling in C-5 of free liver glutamate and the net incorporation of 14C into blood glucose from pyruvate-2-14C. Expand
Major pathways of glycine and serine catabolism in rat liver.
TLDR
Serine catabolism in liver under physiological conditions would proceed mainly by way of preliminary cleavage to methylene-THF and glycine and their subsequent oxidation to yield CO2 as the final product in mitochondria, but can also be catabolized by serine dehydratase in the soluble liver fraction and through other minor pathways. Expand
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References

MEISTER, A., Biochemistry of the amino acids, Academic Press, Inc
  • J. Biol. Chem.,
  • 1947