Gluconeogenesis from alanine in vivo by the ovine fetus and lamb.

  title={Gluconeogenesis from alanine in vivo by the ovine fetus and lamb.},
  author={Ronald L. Prior and Ronald K. Christenson},
  journal={The American journal of physiology},
  volume={233 6},
Gluconeogenesis from alanine was determined with an intravenous infusion of [U-14C]alanine and [6-3H]glucose or [U-14C]glucose in five fetal lambs (3.6 +/- 0.1 kg; 127 days of gestation) and four growing ewe lambs (37 +/- 2 kg). Conversion of alanine to glucose (mmol/h) was 0.40 +/- 0.12 and 0.51 +/- 0.10 and accounted for 7.3 and 25.6% of the alanine turnover in fetal and growing lambs, respectively. Alanine contributed 2.3 and 1.1% of the glucose turnover and 22.3 and 1.1% of the lactate… CONTINUE READING

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