Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 ss-cells.

@article{ElAssaad2010GlucolipotoxicityAL,
  title={Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 ss-cells.},
  author={Wissal El-Assaad and Erik Joly and Annie Barbeau and Robert Sladek and Jean H. Buteau and Isabel Maestre and {\'E}milie Pepin and Shangang Zhao and Jose Iglesias and Enrique Roche and Marc Prentki},
  journal={Endocrinology},
  year={2010},
  volume={151 7},
  pages={3061-73}
}
Elevated glucose and saturated fatty acids synergize in inducing apoptosis in INS832/13 cells and in human islet cells. In order to gain insight into the molecular mechanism(s) of glucolipotoxicity (Gltox), gene profiling and metabolic analyses were performed in INS832/13 cells cultured at 5 or 20 mm glucose in the absence or presence of palmitate. Expression changes were observed for transcripts involved in mitochondrial, lipid, and glucose metabolism. At 24 h after Gltox, increased expression… CONTINUE READING
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