Glucokinase gene variants in Chinese subjects with the common form of NIDDM.


OBJECTIVE To determine whether mutation of the coding or junction region of glucokinase gene (GCK) is also the pathogenic cause of the common form of non-insulin-dependent diabetes mellitus (NIDDM) in Chinese. METHODS Single strand conformation polymorphism (SSCP) analysis was performed after the 12 exons and junction regions of GCK of each subject… (More)