Glucokinase activators AZD6370 and AZD1656 do not affect the central counterregulatory response to hypoglycemia in healthy males.

@article{Norjavaara2012GlucokinaseAA,
  title={Glucokinase activators AZD6370 and AZD1656 do not affect the central counterregulatory response to hypoglycemia in healthy males.},
  author={Ensio Norjavaara and Hans M Ericsson and Folke Sjoeberg and Maria Leonsson-Zachrisson and Mikaela Sj{\"o}strand and Linda Ann. Morrow and Marcus Hompesch},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2012},
  volume={97 9},
  pages={
          3319-25
        }
}
CONTEXT Glucokinase is expressed in the hypothalamus, but effects of glucokinase activators (GKAs) on counterregulatory responses to hypoglycemia are unknown. OBJECTIVE Two separate studies assessed the counterregulatory hormone responses to hypoglycemia induced by the GKAs, AZD6370 and AZD1656, compared with insulin infusion. DESIGN AND SETTING Both studies were randomized, open, two-way crossover studies, conducted in separate clinical research centers. PARTICIPANTS Both studies… CONTINUE READING
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