Glucocorticosteroids stimulate the activity of the promoters of peripheral myelin protein-22 and protein zero genes in Schwann cells.

@article{Desarnaud2000GlucocorticosteroidsST,
  title={Glucocorticosteroids stimulate the activity of the promoters of peripheral myelin protein-22 and protein zero genes in Schwann cells.},
  author={Frank Desarnaud and Sanjay I. Bidichandani and Pragna I. Patel and Etienne Emile Baulieu and Michael Schumacher},
  journal={Brain research},
  year={2000},
  volume={865 1},
  pages={12-6}
}
To better understand the mechanism by which glucocorticosteroids (GLUC) could enhance myelination in the PNS, cultured rat Schwann cells were transiently transfected with reporter constructs in which luciferase expression was controlled by the promoter region of either the peripheral myelin protein-22 (PMP22) or the protein zero (P(0)) genes. GLUC stimulated the activity of the P(0) promoter and the PMP22 promoters 1 and 2. The effect of GLUC was specific as estradiol and testosterone did not… CONTINUE READING

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