Glucocorticoids suppress basal (but not interleukin-1-supported) ovarian phospholipase A2 activity: evidence for glucocorticoid receptor-mediated regulation.

@article{Kol1998GlucocorticoidsSB,
  title={Glucocorticoids suppress basal (but not interleukin-1-supported) ovarian phospholipase A2 activity: evidence for glucocorticoid receptor-mediated regulation.},
  author={S Kol and Izhar Ben-Shlomo and Donna W Payne and Motomu Ando and Richard M. Rohan and Eli Y Adashi},
  journal={Molecular and cellular endocrinology},
  year={1998},
  volume={137 2},
  pages={117-25}
}
Ovulation may constitute a cyclic, inflammatory-like process, wherein the increased expression of interleukin (IL)-1 and the biosynthesis of prostaglandins may be established corollaries. In this communication we hypothesize that glucocorticoids, potent anti-inflammatory principles, may exert an antiovulatory effect by interfering with ovarian IL-1-driven prostaglandin biosynthesis. To test this hypothesis, we examined the effect of treatment with dexamethasone on the activity of ovarian… CONTINUE READING

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