Glucocorticoids regulate somatostatin peptide and steady state messenger ribonucleic acid levels in normal rat tissues and in a somatostatin-producing islet tumor cell line (1027B2).

@article{Papachristou1994GlucocorticoidsRS,
  title={Glucocorticoids regulate somatostatin peptide and steady state messenger ribonucleic acid levels in normal rat tissues and in a somatostatin-producing islet tumor cell line (1027B2).},
  author={Dimitrios N Papachristou and Jiajian Liu and Yogesh C. Patel},
  journal={Endocrinology},
  year={1994},
  volume={134 5},
  pages={2259-66}
}
Although a number of previous studies have suggested that glucocorticoids influence somatostatin (SS) function at the peptide level in some tissues and SS mRNA levels in thyroid tumor cells, there has been no systematic investigation of the effects of glucocorticoids on SS gene expression in normal tissues. In the present study, we have examined the effect of dexamethasone (DEX) on SS secretion and gene expression in rat tissues using as models DEX-treated rats in vivo, primary cultures of rat… CONTINUE READING

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