Glucocorticoids regulate NHE-3 transcription in OKP cells.

  title={Glucocorticoids regulate NHE-3 transcription in OKP cells.},
  author={Michel Baum and Morimasa Amemiya and Vangipuram Dwarakanath and Robert J. Alpern and Orson W Moe},
  journal={The American journal of physiology},
  volume={270 1 Pt 2},
OKP cells express NHE-3, an amiloride-resistant Na+/H+ antiporter, which is likely an isoform responsible for apical proton secretion by the proximal tubule. We have previously shown that an amiloride-resistant Na+/H+ antiporter in OKP cells is regulated by dexamethasone, a synthetic glucocorticoid. The purpose of the present study was to examine the… CONTINUE READING