Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes.

  title={Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes.},
  author={Yi Liu and Joanne M. Cousin and Jeremy Hughes and Jo Van Damme and Jonathan R Seckl and Christopher Haslett and Ian Dransfield and John Savill and Adriano G Rossi},
  journal={Journal of immunology},
  volume={162 6},
Phagocyte recognition, uptake, and nonphlogistic degradation of neutrophils and other leukocytes undergoing apoptosis promote the resolution of inflammation. This study assessed the effects of anti-inflammatory glucocorticoids on this leukocyte clearance mechanism. Pretreatment of "semimature" 5-day human monocyte-derived macrophages (M phi) for 24 h with methylprednisolone, dexamethasone, and hydrocortisone, but not the nonglucocorticoid steroids aldosterone, estradiol, and progesterone… CONTINUE READING