Glucocorticoids produce whole body insulin resistance with changes in cardiac metabolism.

  title={Glucocorticoids produce whole body insulin resistance with changes in cardiac metabolism.},
  author={Dake Qi and Brian Rodrigues},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={292 3},
  • D. QiB. Rodrigues
  • Published 1 March 2007
  • Medicine, Biology
  • American journal of physiology. Endocrinology and metabolism
Insulin resistance is viewed as an insufficiency in insulin action, with glucocorticoids being recognized to play a key role in its pathogenesis. With insulin resistance, metabolism in multiple organ systems such as skeletal muscle, liver, and adipose tissue is altered. These metabolic alterations are widely believed to be important factors in the morbidity and mortality of cardiovascular disease. More importantly, clinical and experimental studies have established that metabolic abnormalities… 

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