Glucocorticoids oppose translational control by leucine in skeletal muscle.

  title={Glucocorticoids oppose translational control by leucine in skeletal muscle.},
  author={O. Jameel Shah and Joshua C. Anthony and Scot R. Kimball and Leonard S. Jefferson},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={279 5},
Glucocorticoids comprise an important class of hormonal mediators of fuel and protein homeostasis in normal and pathological scenarios. In skeletal muscle, exposure to glucocorticoids is characterized by a reduction in protein synthetic rate coincident with hampered translation initiation. However, it is unclear whether this involves attenuation of anabolic stimuli or is simply due to inhibition of the basally activated translational apparatus. Therefore, this inquiry was designed to determine… CONTINUE READING
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