Glucocorticoids modulate TGF-beta production.

  title={Glucocorticoids modulate TGF-beta production.},
  author={Fuqiang Wen and Tadashi Kohyama and Carl Magnus Sk{\"o}ld and Yun Kiu Zhu and Xiangde D Liu and Debra J. Romberger and Julie Stoner and Stephen I. Rennard},
  volume={26 6},
TGF-beta is thought to play a central role in pulmonary fibrosis inducing fibroblast differentiation and extracellular matrix synthesis. In human lung fibroblasts, it is still unclear how various TGB-beta isoforms affect TGF-beta production and whether glucocorticoids, commonly used agents to treat fibrotic lung disease, modulate these processes. To this end, human fetal lung fibroblasts (HFL-1) were cultured with various concentrations of glucocorticoids (budesonide, dexamethasone or… CONTINUE READING


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