Corpus ID: 41838694

Glucocorticoids modulate TGF-beta production by human fetal lung fibroblasts.

@article{Wen2003GlucocorticoidsMT,
  title={Glucocorticoids modulate TGF-beta production by human fetal lung fibroblasts.},
  author={Fu-qiang Wen and Tadashi Kohyama and Carl Magnus Sk{\"o}ld and Yun Kui Zhu and Xiangde Liu and Debra J Romberger and Julie Stoner and Stephen I. Rennard},
  journal={Inflammation},
  year={2003},
  volume={27 1},
  pages={
          9-19
        }
}
TGF-beta1 is thought to play a central role in pulmonary fibrosis inducing fibroblast differentiation and extracellular matrix synthesis. In human lung fibroblasts, it is still unclear how various TGF-beta isoforms affect TGF-beta production and whether glucocorticoids, commonly used agents to treat fibrotic lung disease, modulate these processes. To this end, human fetal lung fibroblasts (HFLF) were cultured with various concentrations of glucocorticoids (budesonide, dexamethasone or… Expand
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