Glucocorticoids modify differentially dopamine- and prostaglandin E1-mediated cyclic AMP formation by the cultured human astrocytoma clone D384.

Abstract

The effects of steroid hormones on the cyclic AMP responses to stimulation of human astrocytoma cells (D384) by dopamine, prostaglandin E1 (PGE1), and isoprenaline were investigated. Incubation of D384 cells with dexamethasone resulted in a potentiation of the PGE1 and isoprenaline responses and a marked attenuation of the dopamine response. The time… (More)

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