Glucocorticoids may enhance oxygen radical-mediated neurotoxicity.

  title={Glucocorticoids may enhance oxygen radical-mediated neurotoxicity.},
  author={Lacey J. McIntosh and Robert Morris Sapolsky},
  volume={17 3-4},
Modern populations are constantly exposed to a variety of compounds in the workplace and the environment that promote formation of reactive oxygen species (ROS) within susceptible tissues. Due to its high oxygen consumption, the brain may be particularly vulnerable to oxidative damage and degeneration. Agents that impact cellular oxidative homeostasis would therefore be expected to alter the toxicity of ROS generating compounds. We are testing this hypothesis using endogenous stress hormones… CONTINUE READING


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