Glucocorticoids inhibit the production of IL6 from monocytes, endothelial cells and fibroblasts.

@article{Waage1990GlucocorticoidsIT,
  title={Glucocorticoids inhibit the production of IL6 from monocytes, endothelial cells and fibroblasts.},
  author={Anders Waage and Geir Slupphaug and Refaat Shalaby},
  journal={European journal of immunology},
  year={1990},
  volume={20 11},
  pages={2439-43}
}
We have examined the effect of dexamethasone (DM) and cortisol on the production of interleukin (IL)6 from the murine macrophage cell line RAW264.9, human monocytes, human endothelial cells and the human fibroblast cell line FS4. In RAW264.9 cells DM in the concentration range 10(-9) M to 10(-6) M inhibited the lipopolysaccharide (LPS)-induced production of IL6 by 10% to 90%. Cortisol had a similar effect, but was about 25 times less potent than DM. Also, when 10(-6) M of DM was added to the… CONTINUE READING

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