Glucocorticoids inhibit the cytokine-induced proliferation of mast cells, the high affinity IgE receptor-mediated expression of TNF-alpha, and the IL-10-induced expression of chymases.

@article{Eklund1997GlucocorticoidsIT,
  title={Glucocorticoids inhibit the cytokine-induced proliferation of mast cells, the high affinity IgE receptor-mediated expression of TNF-alpha, and the IL-10-induced expression of chymases.},
  author={Kari K Eklund and Donald E. Humphries and Zuping Xia and Namit Ghildyal and Daniel Friend and Volker Gross and Richard L. Stevens},
  journal={Journal of immunology},
  year={1997},
  volume={158 9},
  pages={4373-80}
}
Mast cells are a heterogeneous family of immune cells that, when activated through their high affinity IgE receptors (Fc epsilonRI), release various granule mediators (e.g., neutral proteases and serglycin proteoglycans) and proinflammatory cytokines (e.g., IL-6 and TNF-alpha). We and others have shown that the growth and differentiation of immature, nontransformed mouse bone marrow-derived mast cells (mBMMC) can be regulated in vitro by IL-3, IL-10, and c-kit ligand. We now report that… CONTINUE READING

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