Glucocorticoids inhibit proliferation and interleukin-4 and interleukin-5 secretion by aeroallergen-specific T-helper type 2 cell lines.

  title={Glucocorticoids inhibit proliferation and interleukin-4 and interleukin-5 secretion by aeroallergen-specific T-helper type 2 cell lines.},
  author={I. C. Crocker and Martin K. Church and S Newton and Robert G. Townley},
  journal={Annals of allergy, asthma \& immunology : official publication of the American College of Allergy, Asthma, \& Immunology},
  volume={80 6},
  • I. C. CrockerM. Church R. Townley
  • Published 1 June 1998
  • Biology, Medicine
  • Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

Review of the molecular and cellular mechanisms of action of glucocorticoids for use in asthma.

Mometasone furoate (MF), has recently been developed for the treatment of asthma and inhibits key anti-inflammatory processes with a potency equal to or greater than that of fluticasone propionate.

Non‐genomic rapid inhibition of Na+/H+‐exchange 1 and apoptotic immunosuppression in human T cells by glucocorticoids

Whether there is a rapid acidification response caused by an inhibition of NHE1 activity and the differential non‐genomic effect on immunosuppression of hydrocortisone and dexamethasone is explored and apoptosis induced by dexamETHasone and impermeable dexamEthasone–bovine serum albumin suggests that the apoptotic immunosppression occurs through both the plasma membrane and cytoplasmic sites.

Targeting Th2 cells in asthmatic airways.

The most effective anti-asthmatic drugs currently available include inhaled beta2-agonists and glucocorticoids and control asthma in about 95% of patients and may in the future not only control symptoms, but also potentially prevent or cure the disease.

New drugs targeting Th2 lymphocytes in asthma

Drug development for asthma has been directed at improving currently available drugs and findings new compounds that usually target the Th2-driven airway inflammatory response, and drugs targeting disease-inducing Th2 cells are promising therapeutic strategies.

The topical glucocorticoids beclomethasone dipropionate and fluticasone propionate inhibit human T‐cell allergen‐induced production of IL‐5, IL‐3 and GM‐CSF mRNA and protein

T‐cell production of eosinophil‐active cytokines (IL‐5, IL‐3, GM‐CSF) is thought to be fundamental to asthma pathogenesis. Inhaled aeroallergens may be one important stimulus for T‐cell cytokine

Differential Potency of Beclomethasone Esters In‐vitro on Human T‐lymphocyte Cytokine Production and Osteoblast Activity

This work investigated the potency of beclomethasone dipropionate, 17‐beclomet hasone monopropionates and beclometrichasone (compared with dexamethasone as a reference steroid) in two different human cell types, peripheral blood mononuclear cells and osteoblasts.

Anti-angiogenic effects of liposomal prednisolone phosphate on B16 melanoma in mice.



Glucocorticosteroids affect functions of airway- and blood-derived human T-cell clones, favoring the Th1 profile through two mechanisms.

The production of IL-4 and IL-5 by T-cell clones (derived either from BAL or blood) was more sensitive to inhibition by DEX than that of IFN-gamma, which may account for the therapeutic effects of glucocorticosteroids in patients with asthma.

Glucocorticosteroids inhibit leukotriene production.

IL-5 production by bronchoalveolar lavage and peripheral blood mononuclear cells in asthma and atopy.

Elevated IL-5 production is a common feature of BAL cells and PBMC in atopic and nonatopic asthma, and atopic asthmatics show greater IL- 5 production in response to specific allergen compared with atopic nonasthmatics, an effect most marked in BAL cells compared to PBMC.

Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors interleukin 2 and interleukin 4

Production of the murine T cell growth factors interleukin (IL)2 and IL 4 are differentially regulated by glucocorticoid (GCS) hormones, implying that GCS hormones function to control the pattern of lymphokines produced by activated T cells.

Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones.

The data suggest that the presence or the absence of IL-4 and IFN-gamma in bulk cultures of PBMC before cloning may have strong regulatory effects on the in vitro development of human CD4+ T cells into Th1 or Th2 clones.

Hydrocortisone inhibition of human interleukin-4.

Hydrocortisone is demonstrated to inhibit mitogen-induced production of human IL-4, both at the secreted protein, as well as at the mRNA level, which may explain, in part, the immunosuppressive effects of glucocorticoids in the treatment of allergic disease.