Glucocorticoids inhibit proliferation and interleukin-4 and interleukin-5 secretion by aeroallergen-specific T-helper type 2 cell lines.

@article{Crocker1998GlucocorticoidsIP,
  title={Glucocorticoids inhibit proliferation and interleukin-4 and interleukin-5 secretion by aeroallergen-specific T-helper type 2 cell lines.},
  author={I. C. Crocker and Martin K. Church and S Newton and Robert G. Townley},
  journal={Annals of allergy, asthma \& immunology : official publication of the American College of Allergy, Asthma, \& Immunology},
  year={1998},
  volume={80 6},
  pages={
          509-16
        }
}
  • I. C. CrockerM. Church R. Townley
  • Published 1 June 1998
  • Biology, Medicine
  • Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
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36 Citations
Highly Influential Citations
4
Background Citations
9
Methods Citations
3
Results Citations
2

36 Citations

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T‐cell production of eosinophil‐active cytokines (IL‐5, IL‐3, GM‐CSF) is thought to be fundamental to asthma pathogenesis. Inhaled aeroallergens may be one important stimulus for T‐cell cytokine…

Differential Potency of Beclomethasone Esters In‐vitro on Human T‐lymphocyte Cytokine Production and Osteoblast Activity

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References

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The production of IL-4 and IL-5 by T-cell clones (derived either from BAL or blood) was more sensitive to inhibition by DEX than that of IFN-gamma, which may account for the therapeutic effects of glucocorticosteroids in patients with asthma.

Glucocorticoids suppressed production and gene expression of interleukin-5 by peripheral blood mononuclear cells in atopic patients and normal subjects.

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Glucocorticosteroids inhibit leukotriene production.

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