Glucocorticoids inhibit bone resorption by isolated rat osteoclasts by enhancing apoptosis.

@article{Dempster1997GlucocorticoidsIB,
  title={Glucocorticoids inhibit bone resorption by isolated rat osteoclasts by enhancing apoptosis.},
  author={David W. Dempster and Baljit S. Moonga and Lisa S. Stein and W R Horbert and Tony Antakly},
  journal={The Journal of endocrinology},
  year={1997},
  volume={154 3},
  pages={397-406}
}
We have studied the effects of glucocorticoids on the activity and viability of neonatal rat osteoclasts in vitro. In the bone slice assay, glucocorticoids caused a dose-dependent decrease in the amount of bone resorbed, which was accompanied by a parallel decrease in osteoclast number. Loss of osteoclasts was due to their death, which occurred by the process of apoptosis. Evidence for the latter was obtained by a range of techniques, including time-lapse video microscopy, acridine orange… CONTINUE READING